Melilotus officinalis Common name: Sweet clover
Part used: Aerial
Constituents: Coumarin (0.2-0.45 %) and its precursor melilotiside, substituted coumarins (umbelliferone, scopoletin); flavones, caffeic acid derivatives.
Medical actions: Lymphatic, antiedematous, antiinflammatory, possibly antitumor and immune enhancing
Medical uses: Lympedema, venous insufficiency, hemorrhoids, varicose veins, episiotomy, post traumatic inflammation, filaritic lymphedema and elephantiasis, cancer (malignant melanoma, renal cell carcinoma, prostatic carcinoma) particularly to prevent metastasis. Through enhancement of lymphatic function Melilotus increases venous return and is beneficial in post-operative edema.
Pharmacy: Infusion: 5g/cup, TID. Tincture: (1:5), 5ml TID. The therapeutic dose of coumarin has been established at around 1mg/kg/day corresponding to about 10 ml qd of 1:2 fluid exract. Best results occur with 5-6 divided doses. Melilotus may be used long term in this dosage range.
Contraindication: Use with caution with anti-coagulation medications
Toxicity: No adverse effects within the recommended dosage. Avoided in patients with impaired liver function or elevated liver enzymes.