Lycopus virginicus

Common name: Bugleweed/Gypsywort

Family: Lamiaceae

Part used:  Aerial

Constituents:

• Phenolic acid derivatives (caffeic, rosmarinic, chlorogenic, ellagic & luteolin)
• Volatile oil
• Bitter principle
• Manganese

Medicinal actions:

• Anti-hyperthyroid (anti-gonadotropic)
• Astringent
• Diuretic
• Nervine sedative
• Peripheral vasoconstrictor

Medicinal uses:

• Reduces the symptoms of hyperthyroidism including agitation, insomnia, palpitations, and weight loss.
• History of use in the treatment of Graves’ disease & toxic goiter characterized by diffuse hyperplasia of the thyroid gland 

Pharmacology: 

• Phenolic compounds may block TSH from binding to the thyroid and inhibit peripheral T4 conversion
• Inhibits iodine metabolism and thyroxine release from the thyroid gland 

Pharmacy

• Tincture: (1:5, 40%), 5 ml TID; maximum weekly dose 100 ml
• Note: alcohol extract appears to be the most efficacious preparation as it maximizes the amount of phenolic compounds (constituents associated with the anti-thyroid activity)

Toxicity: None reported

Contraindications: Hypothyroidism

Interactions: None known.